With the rapid development of biopharmaceutical technology, major breakthroughs have been continuously achieved in the field of small molecule drug research and development. In this context, pharmaceutical preparations play a pivotal role in improving drug performance, enhancing research and development efficiency, and improving the success rate of clinical research. Amorphous solid dispersions are a preparation technology. The core principle is to mix drug molecules with appropriate polymer carriers so that the drug molecules are evenly dispersed in the polymer matrix to form an amorphous solid solution or suspension. In short, the importance of amorphous solid dispersion technology in the field of drug preparation development is becoming increasingly prominent, and it will become a key means for the development of innovative drugs in the future.


A good amorphous solid dispersion can effectively improve the solubility of the drug and ensure that the improved solubility can remain in a supersaturated state in the simulated biological related medium, thereby being well converted into improved bioavailability. In the continuous theoretical research and practical exploration of academia and industry, a variety of drug solubilization methods have emerged. Among them, amorphous drugs are a new technology that has developed rapidly in recent years, showing broad application prospects in the field of solubilization of poorly soluble drugs.
With decades of experience in providing spray drying solutions for the pharmaceutical industry, Zhiheng has developed a series of new spray dryers that are very mature, reliable and durable. All pharmaceutical-grade spray dryers are specially designed based on Zhiheng's mature spray dryer components to meet the requirements of GMP production.

Zhiheng has developed a new spray dryer for the pharmaceutical industry. In order to meet the special requirements of the pharmaceutical industry for amorphous solid dispersions, we have made some optimizations in atomization performance, system structure and configuration, as a new ideal choice for drying liquid containing organic solvents. The equipment is equipped with a newly developed cyclone separator to capture finer powders, and the tower body is equipped with a cantilevered tower bottom inspection hole or a pneumatic flip top cover. Compared with the conventional cleaning method through the manhole cover, it can clean the tower more thoroughly without dead corners.

The equipment adopts a safer drying process and is suitable for both water-based and organic solvent-based materials. It has been widely used in the pharmaceutical industry.

Flow chart of pharmaceutical spray dryer

The company has an internationally advanced experimental center, dedicated to combining the production process of customers' products with equipment manufacturing and processing, and industrial automation control, and providing customers with drying solutions suitable for their own production processes.